abstract：:The mechanisms underlying memory are under intense investigation. One of the most promising candidates at the cellular level is long-term potentiation (LTP). Numerous pharmacological and molecular genetic manipulations have led to alteration in both LTP and memory. However, the causal relationship between these phenot...

journal_title：Hippocampus

authors： Gerlai R

更新日期：2002-01-01 00:00:00

abstract：:Exposing rats to an enriched environment over an extended period of time has been shown to enhance hippocampal long-term potentiation (LTP). Whether such prolonged exposure to environmental manipulation is necessary for LTP enhancement and whether the environmentally induced enhancement can persist long after the cess...

journal_title：Hippocampus

authors： Tang AC,Zou B

更新日期：2002-01-01 00:00:00

abstract：:Aging is associated with an impaired ability to maintain long-term potentiation (LTP), but the underlying cause of the impairment remains unclear. To gain a better understanding of the cellular and molecular mechanisms responsible for this impairment, the synaptic transmission and plasticity were studied in the CA1 re...

journal_title：Hippocampus

authors： Hsu KS,Huang CC,Liang YC,Wu HM,Chen YL,Lo SW,Ho WC

更新日期：2002-01-01 00:00:00

abstract：:C57 and DBA mice were trained in a crossed maze to assess possible strain differences in place or response learning as a function of training duration (8 or 17 days) and extramaze cueing conditions. The first condition consisted of a diffuse visually cued environment (rich cueing). The second was the same plus an expl...

journal_title：Hippocampus

authors： Passino E,Middei S,Restivo L,Bertaina-Anglade V,Ammassari-Teule M

更新日期：2002-01-01 00:00:00

abstract：:The hippocampus plays an important role in spatial learning and memory. However, the biochemical alterations that subserve this function remain to be fully elucidated. In this study, rats were subjected to a single-trial contextual fear conditioning (CFC) paradigm; the activation of different protein kinase C (PKC) su...

journal_title：Hippocampus

authors： Young E,Cesena T,Meiri KF,Perrone-Bizzozero NI

更新日期：2002-01-01 00:00:00

abstract：:Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes are involved in processing new information while long-term memory (LTM) is being formed. Because brain-derived neutrophic...

journal_title：Hippocampus

authors： Alonso M,Vianna MR,Depino AM,Mello e Souza T,Pereira P,Szapiro G,Viola H,Pitossi F,Izquierdo I,Medina JH

更新日期：2002-01-01 00:00:00

abstract：:Processing of multimodal sensory information by the morphological subdivisions of the hippocampus and its input and output structures was investigated in unanesthetized rabbits by extracellular recording of neuronal activity. Analysis shows principal differences between CA3 neurons with uniform multimodal, mainly inhi...

journal_title：Hippocampus

authors： Vinogradova OS

更新日期：2001-01-01 00:00:00

abstract：:L-aspartate is the amino-acid residue most susceptible to spontaneous isomerization. This denaturation causes an alteration in the biological activity of the protein and is regarded as an aging process of the protein. Protein L-isoaspartyl methyltransferase (PIMT) repairs this post-translational modification and thus ...

journal_title：Hippocampus

authors： Ikegaya Y,Yamada M,Fukuda T,Kuroyanagi H,Shirasawa T,Nishiyama N

更新日期：2001-01-01 00:00:00

abstract：:The electrophysiological properties of neurons in the rat perirhinal cortex were analyzed with intracellular recordings in an in vitro slice preparation. Cells included in this study (n = 59) had resting membrane potential (RMP) = -73.9 +/- 8.5 mV (mean +/- SD), action potential amplitude = 95.5 +/- 10.4 mV, input res...

journal_title：Hippocampus

authors： D'Antuono M,Biagini G,Tancredi V,Avoli M

更新日期：2001-01-01 00:00:00

abstract：:Recent studies have established that environmental factors can modify hippocampal structure and enhance function in adult rodents, but the extent to which genes and the environment exert differential contributions to hippocampal structural integrity in humans is unknown. Here, we applied the twin model in a large samp...

journal_title：Hippocampus

authors： Sullivan EV,Pfefferbaum A,Swan GE,Carmelli D

更新日期：2001-01-01 00:00:00

abstract：:We review evidence from experiments conducted in our laboratory on retrograde amnesia in rats with damage to the hippocampal formation. In a new experiment reported here, we show that N-methyl-D-aspartate (NMDA)-induced hippocampal damage produced retrograde amnesia for both hidden platform and two-choice visible plat...

journal_title：Hippocampus

authors： Sutherland RJ,Weisend MP,Mumby D,Astur RS,Hanlon FM,Koerner A,Thomas MJ,Wu Y,Moses SN,Cole C,Hamilton DA,Hoesing JM

更新日期：2001-01-01 00:00:00

abstract：:To minimize the variability in the extent of lesions made by injections of the excitotoxin ibotenic acid in rhesus monkeys, we developed and validated an MRI-based method to determine the efficacy of the injections soon after surgery. T2-weighted MR images were obtained 6-11 days after surgery from 17 brain hemisphere...

journal_title：Hippocampus

authors： Málková L,Lex CK,Mishkin M,Saunders RC

更新日期：2001-01-01 00:00:00

abstract：:Reorganization of excitatory and inhibitory circuits in the hippocampal formation following seizure-induced neuronal loss has been proposed to underlie the development of chronic seizures in temporal lobe epilepsy (TLE). Here, we investigated whether specific morphological alterations of the GABAergic system can be re...

journal_title：Hippocampus

authors： André V,Marescaux C,Nehlig A,Fritschy JM

更新日期：2001-01-01 00:00:00

abstract：:The mechanisms of Ca2+ responses evoked in hippocampal glial cells in situ, by local application of glutamate and by synaptic activation, were studied in slices from juvenile rats using the membrane permeant fluorescent Ca2+ indicator fluo-3AM and confocal microscopy. Ca2+ responses induced by local application of glu...

journal_title：Hippocampus

authors： Latour I,Gee CE,Robitaille R,Lacaille JC

更新日期：2001-01-01 00:00:00

abstract：:Two recent meta-analyses, drawing on data from many of the same studies with monkeys, reached different conclusions about the relationship between hippocampal damage and recognition memory performance. Both studies found evidence of recognition memory impairment following hippocampal damage. However, Zola et al. (J Ne...

journal_title：Hippocampus

authors： Zola SM,Squire LR

更新日期：2001-01-01 00:00:00

abstract：:For well over a century, ethanol was believed to exert its effects on cognition and behavior by producing a ubiquitous depression of central nervous system activity. A general disruption in brain function was consistent with the belief that ethanol's effects on cognition and behavior were also quite general. Substanti...

journal_title：Hippocampus

authors： White AM,Matthews DB,Best PJ

更新日期：2000-01-01 00:00:00

abstract：:The hippocampus, the prefrontal cortex, and interconnected neural circuits are implicated in several aspects of cognitive and memory processes. The present review is dedicated to the description of the anatomo-functional characteristics of the hippocampo-prefrontal pathway and related neuronal circuits in the rat. Thi...

journal_title：Hippocampus

authors： Thierry AM,Gioanni Y,Dégénétais E,Glowinski J

更新日期：2000-01-01 00:00:00

abstract：:Various forms of synaptic plasticity in the brain have been proposed to result from modifications in the properties of glutamate receptors by calcium-dependent mechanisms. In the present study, changes in glutamate receptors elicited by calcium treatment of previously frozen mouse brain sections were evaluated by qual...

journal_title：Hippocampus

authors： Lapierre L,Valastro B,Miceli D,Massicotte G

更新日期：2000-01-01 00:00:00

abstract：:Accurate and reproducible in vivo measurement of hippocampal volumes using magnetic resonance (MR) imaging is complicated by the morphological complexity of the structure. Additionally, separation of certain parts of the hippocampus from the adjacent brain structures on MR images is sometimes very difficult. These dif...

journal_title：Hippocampus

authors： Pantel J,O'Leary DS,Cretsinger K,Bockholt HJ,Keefe H,Magnotta VA,Andreasen NC

更新日期：2000-01-01 00:00:00

abstract：:Studies of differential eyeblink conditioning (CS+ and CS-) have demonstrated that successful conditioning requires awareness of the stimulus contingencies and that delay conditioning does not. Two experiments were carried out to determine whether awareness is also important for single-cue trace eyeblink conditioning....

journal_title：Hippocampus

authors： Manns JR,Clark RE,Squire LR

更新日期：2000-01-01 00:00:00

abstract：:High-frequency stimulation of excitatory synapses in many regions of the brain triggers a lasting increase in the efficacy of synaptic transmission referred to as long-term potentiation (LTP) and believed to contribute to learning and memory. One hypothesis proposed to account for the stability and properties of this ...

journal_title：Hippocampus

authors： Muller D,Toni N,Buchs PA

更新日期：2000-01-01 00:00:00

abstract：:To examine the effects of long-term potentiation (LTP) on individual neurons in the intact brain, anesthetized rats were implanted with a recording stereotrode in the right CA1 layer of the hippocampus and a stimulating electrode in the right and left CA3 layers. The evoked and spontaneous firing of single CA1 neurons...

journal_title：Hippocampus

authors： Martin PD,Shapiro ML

更新日期：2000-01-01 00:00:00

abstract：:Unilateral injection of kainic acid (KA) into the dorsal hippocampus of adult mice induces spontaneous recurrent partial seizures and replicates histopathological changes observed in human mesial temporal lobe epilepsy (MTLE) (Bouilleret V et al., Neuroscience 1999; 89:717-729). Alterations in pre- and postsynaptic co...

journal_title：Hippocampus

authors： Bouilleret V,Loup F,Kiener T,Marescaux C,Fritschy JM

更新日期：2000-01-01 00:00:00

abstract：:The role of the hippocampus in retrograde amnesia remains controversial and poorly understood. Two cases are reported of discrete bilateral hippocampal damage, one of which was a rare case of limbic encephalitis secondary to the human herpes virus 6. Detailed memory testing showed marked anterograde memory impairment,...

journal_title：Hippocampus

authors： Kapur N,Brooks DJ

更新日期：1999-01-01 00:00:00

abstract：:In the present study, 93 cells in the superior colliculus (SC) were recorded extracellularly during the simultaneous occurrence of spontaneous theta field activity, sensory-induced (tail pinch) theta field activity, and large amplitude irregular (LIA) field activity, recorded from an electrode located in the stratum m...

journal_title：Hippocampus

authors： Natsume K,Hallworth NE,Szgatti TL,Bland BH

更新日期：1999-01-01 00:00:00

abstract：:The effects of intradentate colchicine injections on the performance of tasks requiring spatial working and reference memory are controversial. Multiple-site colchicine injections (7 microg/microl; via a drawn micropipette) throughout the dentate gyrus (DG) of rats (nine sites in each hemisphere, 0.06 microl at each s...

journal_title：Hippocampus

authors： Xavier GF,Oliveira-Filho FJ,Santos AM

更新日期：1999-01-01 00:00:00

abstract：:Functional neuroimaging is uniquely placed to examine the dynamic nature of normal human memory, the distributed brain networks that support it, and how they are modulated. Memory has traditionally been classified into context-specific memories personally experienced ("episodic memory") and impersonal non-context-spec...

journal_title：Hippocampus

authors： Maguire EA,Mummery CJ

更新日期：1999-01-01 00:00:00

abstract：:Trace eyeblink classical conditioning is a non-spatial learning paradigm that requires an intact hippocampus. This task is hippocampus-dependent because the auditory tone conditioned stimulus (CS) is temporally separated from the corneal airpuff unconditioned stimulus (US) by a 500-ms trace interval. Our laboratory ha...

journal_title：Hippocampus

authors： McEchron MD,Disterhoft JF

更新日期：1999-01-01 00:00:00

abstract：:We have studied 5-hydroxytryptamine (5-HT) release in the hippocampal formation following electrical stimulation of the dorsal and median raphé nuclei in the behaving rat. The primary finding in this study is a decrease in neuronal release of serotonin in the dorsal hippocampal formation following electrical stimulati...

journal_title：Hippocampus

authors： Mokler DJ,Lariviere D,Johnson DW,Theriault NL,Bronzino JD,Dixon M,Morgane PJ

更新日期：1998-01-01 00:00:00

abstract：:Synaptic responses mediated by the N-methyl-D-aspartate receptor (NMDAr) and non-NMDAr activation were compared in CA1 hippocampal region of young (3-4 months old) and aged (25-33 months old) Sprague-Dawley rats with the use of ex vivo extracellular recordings techniques. In aged rats, the amplitude of the NMDAr-media...

journal_title：Hippocampus

authors： Jouvenceau A,Dutar P,Billard JM

更新日期：1998-01-01 00:00:00

abstract：:Two experiments assessed the effects of 1) combined subicular complex and posterior cingulate cortical lesions on training-induced neuronal activity (TIA) in the anterior ventral (AV) and medial dorsal (MD) thalamic nuclei; 2) hippocampal (Ammon's horn and dentate gyrus) lesions on TIA in cingulate cortex and in the A...

journal_title：Hippocampus

authors： Kang E,Gabriel M

更新日期：1998-01-01 00:00:00

abstract：:The importance of the perirhinal cortex for visual recognition memory performance is undisputed. However, it has not been clear whether its contribution to performance is mainly perceptual, or mainly mnemonic, or whether the perirhinal cortex contributes to both perception and memory. We determined the effects of medi...

journal_title：Hippocampus

authors： Buffalo EA,Reber PJ,Squire LR

更新日期：1998-01-01 00:00:00

abstract：:Rats were trained on an operant conditional discrimination in which an ambiguous stimulus (X) indicated both the occasions on which responding in the presence of a second cue (A) would be reinforced and the occasions on which responding in the presence of a third cue (B) would not be reinforced (X --> A+, A-, X --> B-...

journal_title：Hippocampus

authors： Han JS,Gallagher M,Holland P

更新日期：1998-01-01 00:00:00

abstract：:In urethane-anesthetized rats, cortical regions which provide distal dendritic excitation of the dentate gyrus and CA1 of the dorsal hippocampus were studied using current source density analysis. Electrical stimulation of the lateral perforant path (LPP) in the lateral angular bundle, lateral entorhinal cortex (LEC),...

journal_title：Hippocampus

authors： Canning KJ,Leung LS

更新日期：1997-01-01 00:00:00

abstract：:Septal nuclei are suggested to work as an interface between the hippocampal formation, involved in higher cognitive functions, and the hypothalamus, involved in motivational behaviors such as feeding, drinking, and intracranial self-stimulation. In the present study, to elucidate a role of the septal nuclei in motivat...

journal_title：Hippocampus

authors： Nishijo H,Kita T,Tamura R,Eifuku S,Terasawa K,Ono T

更新日期：1997-01-01 00:00:00

abstract：:Entorhinal cortex lesion (ECL) leads to anterograde degeneration of perforant path axons and is known to induce a rapid and intense reaction of astrocytes and microglial cells in the deafferented dentate gyrus. Phagocytosis of degenerating axons involves the establishment and maintenance of cell-matrix and cell-cell i...

journal_title：Hippocampus

authors： Hailer NP,Bechmann I,Heizmann S,Nitsch R

更新日期：1997-01-01 00:00:00

abstract：:This study investigated the effects of neonatal hippocampal ablation on the development of spatial learning and memory abilities in rats. Newborn rats sustained bilateral electrolytic lesions of the hippocampus or were sham-operated on postnatal day 1 (PN1). At PN20-25, PN50-55, or PN90-95, separate groups of rats wer...

journal_title：Hippocampus

authors： Altemus KL,Almli CR

更新日期：1997-01-01 00:00:00

abstract：:Structures in the caudal diencephalon including the posterior hypothalamic nucleus, the supramammillary nucleus (SUM) and the nuclei of the mammillary body (MB) occupy a strategic position in the crossroads of ascending and descending traffic between the brainstem and the limbic forebrain (septum/hippocampus). In this...

journal_title：Hippocampus

authors： Kocsis B,Vertes RP

更新日期：1997-01-01 00:00:00

abstract：:Metabolic integrity of glial cells in field CA1 of the guinea pig hippocampus is critical to maintenance of synaptic transmission (Keyser and Pellmar [1994] Glia 10:237-243). To determine if this tight glial-neuronal coupling is equally important in other brain regions, we compared the effect of fluoroacetate (FAC), a...

journal_title：Hippocampus

authors： Keyser DO,Pellmar TC

更新日期：1997-01-01 00:00:00

abstract：:We present a neural network that characterizes a remarkably large number of classical conditioning paradigms and describes the effects of many neurophysiological manipulations. First, the network 1) describes behavior in real time 2) comprises simple and configural stimulus representations, and 3) includes attentional...

journal_title：Hippocampus

authors： Buhusi CV,Schmajuk NA

更新日期：1996-01-01 00:00:00